Meta-tolylsemicarbazid.



UNITED STATES Patented July 19, 1904.

PATENT OFFICE.

JURGEN OALLSEN, OF ELBERFELD, GERMANY, ASSIGNOR TO FARBEN- FABRIKEN OFELBERFELD (30., OF NEW YORK, N. Y., A CORPORA- TION OF NEW YORK.

META-TOLYLSEMICARBAZID.

SPECIFICATION formingpart of Letters Patent No. 765,164, dated Jul 19,1904.

Application filed April 2, 1904. Serial No. 201,341. (No specimens.)

and which, according to my researches, pos- 20 sesses valuabletherapeutic, especially antipyretic, properties, an average dose beingbetween 025 and 0.75 gram.

The process for producing the new com pound consists in treatingmeta-tolylhydrazin 5 or salts thereof with cyanic acid or its salts. Themeta-tolylsemicarbazid thus prooluced represents white lustrouscrystals, melting at from 183 to 184: centigrade. It is only sparinglysoluble in cold water, soluble in hot 3 water and alcohol, and insolublein ether. It reduces an aqueous solution of silver nitrate.

The following example will serve to illustrate the manner in which myinvention can be carried into practical effect. The parts are by weight.To an aqueous solution of 158.5 parts of meta tolylhydrazin hydrochlorideighty-one parts of potassium cyanate dissolved in water are slowlyadded while stirring and cooling. The reaction takes place according tothe following equation: UHFC6H4-NHNH2,HO1+KONO:

' CH3C6H,NHNH-CONH2+C1K. The meta-tolylsemicarbazid thus precipitated isfiltered off and recrystallized from hot water or dilute alcohol, withthe addition of boneblack.

Having now described my invention and in what manner the same is to beperformed, what I claim as new, and desire to secure by Letters Patent,is

The herein-described new meta-tolylsemicarbazid having the formula:

JURGEN CALLSEN.

Witnesses:

OTTO KONIG, J. A. RITTERSHAUS.

